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Management of Pulmonary Arterial Hypertension Associated with Congenital Heart Disease in Children

Received: 6 May 2016     Accepted: 7 August 2016     Published: 11 October 2016
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Abstract

Background Pulmonary arterial hypertension (PAH) is a serious complication of unrepaired congenital heart disease (CHD). The aim of this retrospective study was to evaluate the management of PAH associated with CHD (APAH-CHD) in the Iraqi Center for Heart Disease, Baghdad. Methodology Twenty children with APAH-CHD were surgically treated over 2 years (1st June 2013 to 1st June 2015).Clinical evaluation was followed by chest radiography and transthoracic echocardiography (TTE). Suspected inoperable patients were subjected to cardiac catheterization and Oxygen test. Total surgical correction was elected in children with mild to moderate PAH while young children with low body weight and severe PAH were offered pulmonary artery banding (PAB) reducing PA pressure to 50% of the systemic pressure. All patients were looked after carefully in the ICU. TTE was used in the follow up. Results There were 12 females (F: M=1.5:1) The ages ranged between 4 and 84 months with a mean of 16.4 ± 20.1 months. Seventy % were infants. Five patients (25%) underwent cardiac catheterization. Ventricular septal defect was the commonest underlying anomaly (90%). Twelve patients had full correction and they were significantly older than those treated by PAB. Three totally corrected kids died (25% death) whereas no child died after PAB. Pulmonary hypertensive crisis was accused once. The remaining 17 patients were followed up for 6-18 months; 14 were alive when this paper was written. Conclusion PAB may be a good option for the very young and sick children who might not tolerate a lengthy total correction.

Published in International Journal of Cardiovascular and Thoracic Surgery (Volume 2, Issue 4)
DOI 10.11648/j.ijcts.20160204.11
Page(s) 15-21
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Pulmonary Arterial Hypertension, Associated, Congenital Heart Disease, Children, Eisenmenger’s Syndrome, Pulmonary Artery Banding, Total Correction

References
[1] Montani D, Günther S, Dorfmüller P, Perros F, Girerd B, Garcia G et al. Pulmonary arterial hypertension. Orphanet Journal of Rare Diseases 2013; 8:97 Available from http://www.ojrd.com/content/8/1/97.
[2] Lopes AA, Flores PC, Diaz GF, Mesquita SM. Congenital heart disease and pulmonary arterial hypertension in South America (2013 Grover Conference series). PulmCirc 2014; 4(3): 370-377. DOI: 10.1086/676747.
[3] Frank DB, Hanna BD. Pulmonary Arterial Hypertension Associated with Congenital Heart Disease and Eisenmenger Syndrome: Current Practice in Pediatrics. Minerva Pediatr. 2015 April; 67(2): 169–185.
[4] D’Alto M, Mahadevan VS. Pulmonary arterial hypertension associated with congenital heart disease. EurRespir Rev 2012; 21(126): 328–337 DOI: 10.1183/09059180.00004712.
[5] Warnes CA. Sex Differences in Congenital Heart Disease Should a Woman Be More Like a Man? Circulation. 2008; 118:3-5.
[6] Duffels MG, Engelfriet PM, Berger RM, van Loon RL, Hoendermis E, Vriend JW et al. Pulmonary arterial hypertension in congenital heart disease: An epidemiologic perspective from a Dutch registry. International Journal of Cardiology 2007; 120: 198–204.
[7] John Berger. Pulmonary Hypertension in Congenital Heart Disease [monograph on the internet] [cited on 22-12-2015] available from http://www.medscape.org/viewarticle/551739.
[8] Kyle WB. Pulmonary Hypertension Associated with Congenital Heart Disease: A Practical Review for the Pediatric Cardiologist. Congenit Heart Dis 2012; 7: 575–583.
[9] ShabirBhimji. Pulmonary artery banding [monograph on the internet]. In: John Kupferschmid, chief editor. [Cited on 1-9-2015] Available from: http://emedicine.medscape.com/article/905353-overview#showall.
[10] Adatia I, Kothari SS, Feinstein JA. Pulmonary Hypertension Associated With Congenital Heart Disease Pulmonary Vascular Disease: The Global Perspective. CHEST 2010; 137(6) (Suppl): 52S–61S.
[11] Gatzoulis MA, Alonso-Gonzalez R, Beghetti M. Pulmonary arterial hypertension in paediatric and adult patients with congenital heart disease. EurRespir Rev 2009; 18: 113, 154–161.
[12] Van Loon RL, Roofthooft MT, Hillege HL, ten Harkel AD, van Osch-Gevers M, Delhaas T et al. Pediatric Pulmonary Hypertension in the Netherlands Epidemiology and Characterization during the Period 1991 to 2005. Circulation 2011; 124: 1755-1764.
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  • APA Style

    Abdulsalam Y. Taha, Ahmed M. Ibraheem. (2016). Management of Pulmonary Arterial Hypertension Associated with Congenital Heart Disease in Children. International Journal of Cardiovascular and Thoracic Surgery, 2(4), 15-21. https://doi.org/10.11648/j.ijcts.20160204.11

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    ACS Style

    Abdulsalam Y. Taha; Ahmed M. Ibraheem. Management of Pulmonary Arterial Hypertension Associated with Congenital Heart Disease in Children. Int. J. Cardiovasc. Thorac. Surg. 2016, 2(4), 15-21. doi: 10.11648/j.ijcts.20160204.11

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    AMA Style

    Abdulsalam Y. Taha, Ahmed M. Ibraheem. Management of Pulmonary Arterial Hypertension Associated with Congenital Heart Disease in Children. Int J Cardiovasc Thorac Surg. 2016;2(4):15-21. doi: 10.11648/j.ijcts.20160204.11

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  • @article{10.11648/j.ijcts.20160204.11,
      author = {Abdulsalam Y. Taha and Ahmed M. Ibraheem},
      title = {Management of Pulmonary Arterial Hypertension Associated with Congenital Heart Disease in Children},
      journal = {International Journal of Cardiovascular and Thoracic Surgery},
      volume = {2},
      number = {4},
      pages = {15-21},
      doi = {10.11648/j.ijcts.20160204.11},
      url = {https://doi.org/10.11648/j.ijcts.20160204.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcts.20160204.11},
      abstract = {Background Pulmonary arterial hypertension (PAH) is a serious complication of unrepaired congenital heart disease (CHD). The aim of this retrospective study was to evaluate the management of PAH associated with CHD (APAH-CHD) in the Iraqi Center for Heart Disease, Baghdad. Methodology Twenty children with APAH-CHD were surgically treated over 2 years (1st June 2013 to 1st June 2015).Clinical evaluation was followed by chest radiography and transthoracic echocardiography (TTE). Suspected inoperable patients were subjected to cardiac catheterization and Oxygen test. Total surgical correction was elected in children with mild to moderate PAH while young children with low body weight and severe PAH were offered pulmonary artery banding (PAB) reducing PA pressure to 50% of the systemic pressure. All patients were looked after carefully in the ICU. TTE was used in the follow up. Results There were 12 females (F: M=1.5:1) The ages ranged between 4 and 84 months with a mean of 16.4 ± 20.1 months. Seventy % were infants. Five patients (25%) underwent cardiac catheterization. Ventricular septal defect was the commonest underlying anomaly (90%). Twelve patients had full correction and they were significantly older than those treated by PAB. Three totally corrected kids died (25% death) whereas no child died after PAB. Pulmonary hypertensive crisis was accused once. The remaining 17 patients were followed up for 6-18 months; 14 were alive when this paper was written. Conclusion PAB may be a good option for the very young and sick children who might not tolerate a lengthy total correction.},
     year = {2016}
    }
    

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  • TY  - JOUR
    T1  - Management of Pulmonary Arterial Hypertension Associated with Congenital Heart Disease in Children
    AU  - Abdulsalam Y. Taha
    AU  - Ahmed M. Ibraheem
    Y1  - 2016/10/11
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    T2  - International Journal of Cardiovascular and Thoracic Surgery
    JF  - International Journal of Cardiovascular and Thoracic Surgery
    JO  - International Journal of Cardiovascular and Thoracic Surgery
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    PB  - Science Publishing Group
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    AB  - Background Pulmonary arterial hypertension (PAH) is a serious complication of unrepaired congenital heart disease (CHD). The aim of this retrospective study was to evaluate the management of PAH associated with CHD (APAH-CHD) in the Iraqi Center for Heart Disease, Baghdad. Methodology Twenty children with APAH-CHD were surgically treated over 2 years (1st June 2013 to 1st June 2015).Clinical evaluation was followed by chest radiography and transthoracic echocardiography (TTE). Suspected inoperable patients were subjected to cardiac catheterization and Oxygen test. Total surgical correction was elected in children with mild to moderate PAH while young children with low body weight and severe PAH were offered pulmonary artery banding (PAB) reducing PA pressure to 50% of the systemic pressure. All patients were looked after carefully in the ICU. TTE was used in the follow up. Results There were 12 females (F: M=1.5:1) The ages ranged between 4 and 84 months with a mean of 16.4 ± 20.1 months. Seventy % were infants. Five patients (25%) underwent cardiac catheterization. Ventricular septal defect was the commonest underlying anomaly (90%). Twelve patients had full correction and they were significantly older than those treated by PAB. Three totally corrected kids died (25% death) whereas no child died after PAB. Pulmonary hypertensive crisis was accused once. The remaining 17 patients were followed up for 6-18 months; 14 were alive when this paper was written. Conclusion PAB may be a good option for the very young and sick children who might not tolerate a lengthy total correction.
    VL  - 2
    IS  - 4
    ER  - 

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Author Information
  • Department of Cardiothoracic & Vascular Surgery, School of Medicine, University of Sulaimaniyah and Sulaimaniyah Teaching Hospital, Sulaimaniyah, Region of Kurdistan, Iraq

  • Department of Cardiac Surgery, Iraqi Center for Heart Disease (ICHD), Baghdad, Iraq

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