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Mediastinal Pseudo-Tumor Tuberculosis Associated with Systemic Lupus Erythematosus

Received: 27 May 2017     Accepted: 16 June 2017     Published: 24 October 2017
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Abstract

We report the singular association of mediastinal pseudo-tumoral tuberculosis [TB] with systemic lupus erythematosus [SLE]. D. I, 22 years old woman, is followed for a SLE since 2006 controlled by hydrochloroquine ‘HCQ’200mg twice/day and a thyroiditis of Hashimoto under levothyrox 125 mg/d. It does not relate to tuberculosis. She is hospitalized in pneumology for progressive dyspnea and chest pain. Objective clinical examination shows a conserved general condition, apyrexia T° to 37, BMI to 21.1 (without notion of loss of weight), heart beat 94 / min, respiratory rate at 24 cycle/min and blood pressure at 110/60 mmHg. The pleuropulmonary and cardiovascular examination were without abnormality and thus the remainder of the clinical examination. The image of the thoracic face fails with a right para-cardiac opacity erasing the right edge of the cortex and the CT concludes to a mediastinal tumoral process, filling the gutter vertebral and extending from T6 to T10, with tissue density presenting areas of necrosis within it. Bronchial fibroscopy finds a thickening of inter-lobar spurs and bronchial biopsies identifies a bronchial mucosa site of chronic inflammatory remodeling with presence of multi-nucleated giant cells suggesting a tuberculoid process. The parameters of the hemogram were normal and the inflammatory syndrome was attested by both the increase ERS at 54 mm and the level of CRP at 12 mg/l. The smears, negative on direct examination, will prove positive for culture on Lowenstein medium. Antituberculosis treatment has been prescribed with good clinical, bacteriological and radiological progress. Long-term asymptomatic mediastinal pseudo-tumoral tuberculosis can be revealed at the compressive stage by dyspnea and chest pain. The fear of lymphoma requires biopsies with pathological examinations which sometimes reveal benign affections (tuberculosis, sarcoidosis in their tumor forms) which can enamel the autoimmune disorders characterizing a SLE.

Published in International Journal of Cardiovascular and Thoracic Surgery (Volume 3, Issue 5)
DOI 10.11648/j.ijcts.20170305.15
Page(s) 63-66
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Mediastinal Pseudo Tumor, Tuberculosis, Systemic Lupus Erythematosus

References
[1] Yehuda Shoenfeld MD; Boris Gilburd PhD; Mahmud Abu-Shakra MD The Mosaic of Autoimmunity: Genetic Factors Involved in Autoimmune Diseases – 2008 The Mosaic of Autoimmunity, IMAJ 2008; 10: 3–7.
[2] Y. Shoenfeld et al. The Mosaic of Autoimmunity: Prediction, Autoantibodies, and Therapy in Autoimmune Diseases – 2008; IMAJ 2008; 10: 13–19.
[3] Ricard Cervera et all, and the European Working Party on Systemic Lupus Erythematosus; Morbidity and Mortality in Systemic Lupus Erythematosus During a 10-Year Period A Comparison of Early and Late Manifestations in a Cohort of 1,000 Patients (Medicine 2003; 82: 299–308).
[4] Jacqueline Trager, MD, and Michael M. Ward, MD, MPH* Mortality and causes of death in systemic lupus erythematosusCurrent Opinion in Rheumatology 2001, 13: 345–351.
[5] Gian Domenico Sebastiani, Annamaria Iuliano, Immacolata Prevete & Giovanni Minisola. Opportunistic infections in systemic lupus erythematosus Int. J. Clin. Rheumatol. (2012) 7 (3), 275–279.
[6] A. Doria, M. Canova, M. Tonon, M. Zen, E. Rampudda, N. Bassi, F. Atzeni, S. Zampier, A. Ghirardello, Infections as triggers and complications of systemic lupus erythematosus. Autoimmunity Reviews 8 (2008) 24–28.
[7] J.-E. Yun, S.-W. Lee, T.-H. Kim, J.-B. Jun, S. Jung, S.-C. Bae, T.-Y. Kim, D. -H. YooThe incidence and clinical characteristics of Mycobacteriutuberculosis infection among systemic lupus erythematosusand rheumatoid arthritis patients in Korea Clinical and Experimental Rheumatology 2002; 20: 127-132.
[8] Harikrishna et al. Disseminated tuberculosis in a patient with systemic lupus erythematosus. J ClinSci Res 2012; 1: 199-203.
[9] Kunchok Dorjee, Kerry L Dierberg, Tsetan D Sadutshang and Arthur L Reingold First report of multi-drug resistant tuberculosis in a systemic lupus erythematosus Patient. Dorjee et al. BMC Res Notes (2015) 8: 337.
[10] Savino Sciascia, Maria Jose Cuadrado, Mohammed Yousuf Karim, Management of infection in systemic lupus erythematosus; Best Practice & Research Clinical Rheumatology 27 (2013) 377–389.
[11] Prasanta Raghab Mohapatra, Ashok Kumar Janmeja; tuberculous Lymphadenitis; J Assoc Physician India August 2009; 57: 585-590.
[12] Maguireet al. Isolated anterior mediastinal tuberculosis in an immunocompetent patient BMC Pulmonary Medicine (2016) 16: 24.
[13] Kim et al. Pulmonary Tuberculosis in Patients with Systemic Lupus Erythematosus; AJR December 1999; 173: 1639-1642.
[14] F. M. Ribeiro & M. Szyper-Kravitz & E. M. Klumb & G. Lannes & F. R. E. Ribeiro & E. M. M. Albuquerque & Y. Shoenfeld, Can Lupus Flares be Associated with Tuberculosis Infection? Clinic Rev Allerg Immunol (2010) 38: 163–168.
[15] Hanspeter Waldner; The role of innate immune responses in autoimmune disease development; Autoimmunity Reviews 8 (2009) 400–404.
[16] Barri J, Fessler MD, infection diseases in systemic lupus erythematosus: risk factors, management and prophylaxis; Best Practice and Research Clinical Rhumatology 16, No 2, pp. 281-291, 2002.
[17] A. A. WADEE, A. J. GEAR & A. R. RABSON, Production of a suppressor factor by human adherent cells treated with Mycobacterium tuberculosis: absence in systemic lupus erythematosus; Clin. exp. Immunol. (1981) 46, 82-88.
[18] María del Mar Arenas Miras, Carmen Hidalgo Tenorio, y Juan Jimenez AlonsoLa infección tuberculosa en pacientes con lupus eritematososistémico: situaciónen Espana; Reumatol Clin. 2013; 9 (6): 369–372 (esspaneol).
[19] Judith A. James, Andrea L. Sestak, and Evan S. Vista SLE and Infections (DUBOIS’ Lupus Erythematosus and Related Syndrome Edited by Daniel J. Wallace, MD, FACP, FACR; Bevra Hannahs Hahn, MD); (2012), 45; 555-562.
[20] Graziela Carvalheiras, Mariana Brandão, Vital Domingues, Esmeralda Neve, Júlia Vasconcelos, Isabel Almeida, Carlos Vasconcelos; Lymphocytes and Infection in Autoimmune Diseases ( infection and autoimmunity Second Edition Edited by YEHUDA SHOENFELD, NANCY AGMON-LEVIN, NOEL R. ROSE), (2015), 7; 109-131.
[21] Milan Buc and Jozef Rovensk; Tuberculosis and SLE-Like Symptoms as a Complication of Biological Anti-TNF Therapy (Infection and Autoimmunity edited by Y. Shoenfeld and N. R. Rose) (2004); 623-628.
Cite This Article
  • APA Style

    Nassima Dekdouk, Djennette Hakem, Karima Abbaci, Nassima Djami, Rabah Amrane, et al. (2017). Mediastinal Pseudo-Tumor Tuberculosis Associated with Systemic Lupus Erythematosus. International Journal of Cardiovascular and Thoracic Surgery, 3(5), 63-66. https://doi.org/10.11648/j.ijcts.20170305.15

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    ACS Style

    Nassima Dekdouk; Djennette Hakem; Karima Abbaci; Nassima Djami; Rabah Amrane, et al. Mediastinal Pseudo-Tumor Tuberculosis Associated with Systemic Lupus Erythematosus. Int. J. Cardiovasc. Thorac. Surg. 2017, 3(5), 63-66. doi: 10.11648/j.ijcts.20170305.15

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    AMA Style

    Nassima Dekdouk, Djennette Hakem, Karima Abbaci, Nassima Djami, Rabah Amrane, et al. Mediastinal Pseudo-Tumor Tuberculosis Associated with Systemic Lupus Erythematosus. Int J Cardiovasc Thorac Surg. 2017;3(5):63-66. doi: 10.11648/j.ijcts.20170305.15

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  • @article{10.11648/j.ijcts.20170305.15,
      author = {Nassima Dekdouk and Djennette Hakem and Karima Abbaci and Nassima Djami and Rabah Amrane and Rafika Boughrarou and Brahim Mansouri and Abdelkrim Berrah},
      title = {Mediastinal Pseudo-Tumor Tuberculosis Associated with Systemic Lupus Erythematosus},
      journal = {International Journal of Cardiovascular and Thoracic Surgery},
      volume = {3},
      number = {5},
      pages = {63-66},
      doi = {10.11648/j.ijcts.20170305.15},
      url = {https://doi.org/10.11648/j.ijcts.20170305.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcts.20170305.15},
      abstract = {We report the singular association of mediastinal pseudo-tumoral tuberculosis [TB] with systemic lupus erythematosus [SLE]. D. I, 22 years old woman, is followed for a SLE since 2006 controlled by hydrochloroquine ‘HCQ’200mg twice/day and a thyroiditis of Hashimoto under levothyrox 125 mg/d. It does not relate to tuberculosis. She is hospitalized in pneumology for progressive dyspnea and chest pain. Objective clinical examination shows a conserved general condition, apyrexia T° to 37, BMI to 21.1 (without notion of loss of weight), heart beat 94 / min, respiratory rate at 24 cycle/min and blood pressure at 110/60 mmHg. The pleuropulmonary and cardiovascular examination were without abnormality and thus the remainder of the clinical examination. The image of the thoracic face fails with a right para-cardiac opacity erasing the right edge of the cortex and the CT concludes to a mediastinal tumoral process, filling the gutter vertebral and extending from T6 to T10, with tissue density presenting areas of necrosis within it. Bronchial fibroscopy finds a thickening of inter-lobar spurs and bronchial biopsies identifies a bronchial mucosa site of chronic inflammatory remodeling with presence of multi-nucleated giant cells suggesting a tuberculoid process. The parameters of the hemogram were normal and the inflammatory syndrome was attested by both the increase ERS at 54 mm and the level of CRP at 12 mg/l. The smears, negative on direct examination, will prove positive for culture on Lowenstein medium. Antituberculosis treatment has been prescribed with good clinical, bacteriological and radiological progress. Long-term asymptomatic mediastinal pseudo-tumoral tuberculosis can be revealed at the compressive stage by dyspnea and chest pain. The fear of lymphoma requires biopsies with pathological examinations which sometimes reveal benign affections (tuberculosis, sarcoidosis in their tumor forms) which can enamel the autoimmune disorders characterizing a SLE.},
     year = {2017}
    }
    

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  • TY  - JOUR
    T1  - Mediastinal Pseudo-Tumor Tuberculosis Associated with Systemic Lupus Erythematosus
    AU  - Nassima Dekdouk
    AU  - Djennette Hakem
    AU  - Karima Abbaci
    AU  - Nassima Djami
    AU  - Rabah Amrane
    AU  - Rafika Boughrarou
    AU  - Brahim Mansouri
    AU  - Abdelkrim Berrah
    Y1  - 2017/10/24
    PY  - 2017
    N1  - https://doi.org/10.11648/j.ijcts.20170305.15
    DO  - 10.11648/j.ijcts.20170305.15
    T2  - International Journal of Cardiovascular and Thoracic Surgery
    JF  - International Journal of Cardiovascular and Thoracic Surgery
    JO  - International Journal of Cardiovascular and Thoracic Surgery
    SP  - 63
    EP  - 66
    PB  - Science Publishing Group
    SN  - 2575-4882
    UR  - https://doi.org/10.11648/j.ijcts.20170305.15
    AB  - We report the singular association of mediastinal pseudo-tumoral tuberculosis [TB] with systemic lupus erythematosus [SLE]. D. I, 22 years old woman, is followed for a SLE since 2006 controlled by hydrochloroquine ‘HCQ’200mg twice/day and a thyroiditis of Hashimoto under levothyrox 125 mg/d. It does not relate to tuberculosis. She is hospitalized in pneumology for progressive dyspnea and chest pain. Objective clinical examination shows a conserved general condition, apyrexia T° to 37, BMI to 21.1 (without notion of loss of weight), heart beat 94 / min, respiratory rate at 24 cycle/min and blood pressure at 110/60 mmHg. The pleuropulmonary and cardiovascular examination were without abnormality and thus the remainder of the clinical examination. The image of the thoracic face fails with a right para-cardiac opacity erasing the right edge of the cortex and the CT concludes to a mediastinal tumoral process, filling the gutter vertebral and extending from T6 to T10, with tissue density presenting areas of necrosis within it. Bronchial fibroscopy finds a thickening of inter-lobar spurs and bronchial biopsies identifies a bronchial mucosa site of chronic inflammatory remodeling with presence of multi-nucleated giant cells suggesting a tuberculoid process. The parameters of the hemogram were normal and the inflammatory syndrome was attested by both the increase ERS at 54 mm and the level of CRP at 12 mg/l. The smears, negative on direct examination, will prove positive for culture on Lowenstein medium. Antituberculosis treatment has been prescribed with good clinical, bacteriological and radiological progress. Long-term asymptomatic mediastinal pseudo-tumoral tuberculosis can be revealed at the compressive stage by dyspnea and chest pain. The fear of lymphoma requires biopsies with pathological examinations which sometimes reveal benign affections (tuberculosis, sarcoidosis in their tumor forms) which can enamel the autoimmune disorders characterizing a SLE.
    VL  - 3
    IS  - 5
    ER  - 

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Author Information
  • Department of Internal Medicine, Mohammad-Lamine-Debaghine Hospital, Algeries, Algeria

  • Department of Internal Medicine, Mohammad-Lamine-Debaghine Hospital, Algeries, Algeria

  • Department of Internal Medicine, Mohammad-Lamine-Debaghine Hospital, Algeries, Algeria

  • Department of Pneumo-Phtisiology, Mohammad-Lamine-Debaghine Hospital, Algeries, Algeria

  • Department of Pneumo-Phtisiology, Mohammad-Lamine-Debaghine Hospital, Algeries, Algeria

  • Department of Radiology, Mohammad-Lamine-Debaghine Hospital, Algeries, Algeria

  • Department of Radiology, Mohammad-Lamine-Debaghine Hospital, Algeries, Algeria

  • Department of Internal Medicine, Mohammad-Lamine-Debaghine Hospital, Algeries, Algeria

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