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Obstructive Thrombosis of a Mitral Prosthetic Valve in the Context of COVID-19 in Senegal

Received: 31 May 2023     Accepted: 18 July 2023     Published: 5 August 2023
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Abstract

COVID-19 causes a hypercoagulable state, predisposing to a thrombotic state, particularly in patients with mechanical valve. Thrombosis of a prosthetic valve is a rare but serious complication of valve replacement by mechanical prosthesis. It is a medical and surgical emergency. Diagnosis is based primarily on trans-thoracic echocardiography. All obstructive thromboses of the left heart require surgery. We report the case of a 30-year-old female patient with a background COVID-19 infection who presented with New York Heart Association (NYHA) class III dyspnea, chest pain and fever, a transthoracic echocardiography showed obstructive mechanical mitral valve thrombosis. She was hospitalized in the cardiology department and anticoagulant therapy was initiated. The mechanical valve was, then, removed. On H15 postoperatively she was febrile with a temperature of (40°C), the pupils were isocoric, and there was a decerebrate rigidity, however, her hemodynamic state was stable. The PCR test result for COVID-19 was positive 15 hours after the surgery, a thoracic computer tomography angiography scan revealed a mild form of COVID-19. A brain computer tomography scan revealed a COVID-19 encephalopathy. Unfortunately at H20, the infectious workup showed leucocytosis and a positive CRP, which required initiating empiric antibiotic therapy with ceftriaxone and gentamicin awaiting for microscopy, culture and sensitivity results. Treatment with methylprednisolone was also started. The dose of immediate postoperative anticoagulation was maintained at 200 IU/Kg/D. On H24 her Glasgow Coma Scale was 3/15, pupils were fixed and dilated with loss of brainstem reflexes. Death was declared at Day 2 postoperatively as a result of neurological complications. Standard prophylactic and therapeutic protocols need to be reviewed when COVID-19 occurs in a patient with a mechanical valve prosthesis.

Published in International Journal of Cardiovascular and Thoracic Surgery (Volume 9, Issue 4)
DOI 10.11648/j.ijcts.20230904.12
Page(s) 51-55
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Mechanical Valve Thrombosis, COVID-19, Anticoagulation

References
[1] WHO. Rheumatic Fever and rheumatic heart disease: report of a WHO expert consultation. Geneva: World Health organization, 2004.
[2] Sabahattin Gündüz, Macit Kalçık, Mustafa Ozan Gürsoy and al (2020): Diagnosis, treatment & management of prosthetic valve thrombosis: the key considerations, Expert Review of Medical Devices, 2020 Mar; 17 (3): 209-221.
[3] M Y Abou-Ismail, A Diamond, S Kapoor and al. The hypercoagulable state in COVID-19: Incidence, pathophysiology, and management. Thromb Res. 2020 Oct; 194: 101-115.
[4] Silbert H, Khan SS, Matloff The St Jude valve: thrombolysis as the first line of therapy for cardiac valve replacement. Circulation 1993; 87: 30.
[5] Dürrleman N, Pellerin M, Bouchard D, Prosthetic valve thrombosis: twenty-year experience at the Montreal Heart Institute. J Thorac Cardiovasc Surg 2004; 127: 1388-1392.
[6] Katneni U, Alexaki A, Hunt R C et al: Coagulopathy and Thrombosis as a Result of Severe COVID-19 Infection: A Microvascular Focus. Thromb Haemost. 2020 Dec; 120 (12): 1668-1679.
[7] Chauban A J, Wiffen L, Brown T COVID-19: A collision of complement, coagulation and inflammatory pathways. J Thromb and Haemost Volume 18, Issue 9 p. 2110-2117.
[8] Iba T, Levy J, Levi M et al Coagulopathy in COVID-19 J Thromb and Haemost. 2020 Sep; 18 (9): 2103-2109.
[9] Langer F, Kluge S, Klamroth R et al Coagulopathy in COVID-19 and Its Implication for Safe and Efficacious Thromboprophylaxis. Hamostaseologie 2020 Aug; 40 (3): 264-269.
[10] Fontana P, Casini A, Robert-Ebadi H, Glauser F, Righini M, Blondon M. Venous thromboembolism in COVID-19: systematic review of reported risks and current guidelines. Swiss Med Wkly. 2020; 150: w 20301.
[11] Manolis A S, Manolis T A, Manolis A A et al COVID-19 Infection: Viral Macro- and Micro-Vascular Coagulopathy and Thromboembolism/Prophylactic and Therapeutic Management. J Cardiovasc Pharmacol Ther 2021 Jan; 26 (1): 12–24.
[12] Di Micco P, Tufano A, Cardillo G and al, The impact of risk-adjusted heparin regimens on the outcome of patients with Codis 19 infection. Viruses 2021; 13: 1720.
[13] Jeckelmann C, Djokic B, Duchatelle V and al Case report: Mechanical mitral prosthetic valve thrombosis in the context of COVID-19 despite effective anticoagulation. European Heart Journal-case reports (2022); 6 (2), 1-6.
[14] Roudaut R, Serri K, and Lafitte S. Thrombosis of prosthetic heart valves: diagnosis and therapeutic considerations. Heart. 2007 Jan; 93 (1): 137-142.
[15] Pibarot P, Dumesnil JG, Prosthetic heart valve: selection of optimal prosthetic and long-term management. Circulation. 2009; 119: 1034-48.
Cite This Article
  • APA Style

    Ba Papa Ousmane, Diagne Papa Amath, Diop Momar Sokhna, Ismael Ibouroi Moina-Hanifa, Ikponmwosa Gold, et al. (2023). Obstructive Thrombosis of a Mitral Prosthetic Valve in the Context of COVID-19 in Senegal. International Journal of Cardiovascular and Thoracic Surgery, 9(4), 51-55. https://doi.org/10.11648/j.ijcts.20230904.12

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    ACS Style

    Ba Papa Ousmane; Diagne Papa Amath; Diop Momar Sokhna; Ismael Ibouroi Moina-Hanifa; Ikponmwosa Gold, et al. Obstructive Thrombosis of a Mitral Prosthetic Valve in the Context of COVID-19 in Senegal. Int. J. Cardiovasc. Thorac. Surg. 2023, 9(4), 51-55. doi: 10.11648/j.ijcts.20230904.12

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    AMA Style

    Ba Papa Ousmane, Diagne Papa Amath, Diop Momar Sokhna, Ismael Ibouroi Moina-Hanifa, Ikponmwosa Gold, et al. Obstructive Thrombosis of a Mitral Prosthetic Valve in the Context of COVID-19 in Senegal. Int J Cardiovasc Thorac Surg. 2023;9(4):51-55. doi: 10.11648/j.ijcts.20230904.12

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  • @article{10.11648/j.ijcts.20230904.12,
      author = {Ba Papa Ousmane and Diagne Papa Amath and Diop Momar Sokhna and Ismael Ibouroi Moina-Hanifa and Ikponmwosa Gold and Dioum Momar and Ba El Hadj Boubacar and Bizrane Myriam and Ba Papa Salmane and Ciss Amadou Gabriel},
      title = {Obstructive Thrombosis of a Mitral Prosthetic Valve in the Context of COVID-19 in Senegal},
      journal = {International Journal of Cardiovascular and Thoracic Surgery},
      volume = {9},
      number = {4},
      pages = {51-55},
      doi = {10.11648/j.ijcts.20230904.12},
      url = {https://doi.org/10.11648/j.ijcts.20230904.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcts.20230904.12},
      abstract = {COVID-19 causes a hypercoagulable state, predisposing to a thrombotic state, particularly in patients with mechanical valve. Thrombosis of a prosthetic valve is a rare but serious complication of valve replacement by mechanical prosthesis. It is a medical and surgical emergency. Diagnosis is based primarily on trans-thoracic echocardiography. All obstructive thromboses of the left heart require surgery. We report the case of a 30-year-old female patient with a background COVID-19 infection who presented with New York Heart Association (NYHA) class III dyspnea, chest pain and fever, a transthoracic echocardiography showed obstructive mechanical mitral valve thrombosis. She was hospitalized in the cardiology department and anticoagulant therapy was initiated. The mechanical valve was, then, removed. On H15 postoperatively she was febrile with a temperature of (40°C), the pupils were isocoric, and there was a decerebrate rigidity, however, her hemodynamic state was stable. The PCR test result for COVID-19 was positive 15 hours after the surgery, a thoracic computer tomography angiography scan revealed a mild form of COVID-19. A brain computer tomography scan revealed a COVID-19 encephalopathy. Unfortunately at H20, the infectious workup showed leucocytosis and a positive CRP, which required initiating empiric antibiotic therapy with ceftriaxone and gentamicin awaiting for microscopy, culture and sensitivity results. Treatment with methylprednisolone was also started. The dose of immediate postoperative anticoagulation was maintained at 200 IU/Kg/D. On H24 her Glasgow Coma Scale was 3/15, pupils were fixed and dilated with loss of brainstem reflexes. Death was declared at Day 2 postoperatively as a result of neurological complications. Standard prophylactic and therapeutic protocols need to be reviewed when COVID-19 occurs in a patient with a mechanical valve prosthesis.},
     year = {2023}
    }
    

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    T1  - Obstructive Thrombosis of a Mitral Prosthetic Valve in the Context of COVID-19 in Senegal
    AU  - Ba Papa Ousmane
    AU  - Diagne Papa Amath
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    AU  - Ismael Ibouroi Moina-Hanifa
    AU  - Ikponmwosa Gold
    AU  - Dioum Momar
    AU  - Ba El Hadj Boubacar
    AU  - Bizrane Myriam
    AU  - Ba Papa Salmane
    AU  - Ciss Amadou Gabriel
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    T2  - International Journal of Cardiovascular and Thoracic Surgery
    JF  - International Journal of Cardiovascular and Thoracic Surgery
    JO  - International Journal of Cardiovascular and Thoracic Surgery
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    PB  - Science Publishing Group
    SN  - 2575-4882
    UR  - https://doi.org/10.11648/j.ijcts.20230904.12
    AB  - COVID-19 causes a hypercoagulable state, predisposing to a thrombotic state, particularly in patients with mechanical valve. Thrombosis of a prosthetic valve is a rare but serious complication of valve replacement by mechanical prosthesis. It is a medical and surgical emergency. Diagnosis is based primarily on trans-thoracic echocardiography. All obstructive thromboses of the left heart require surgery. We report the case of a 30-year-old female patient with a background COVID-19 infection who presented with New York Heart Association (NYHA) class III dyspnea, chest pain and fever, a transthoracic echocardiography showed obstructive mechanical mitral valve thrombosis. She was hospitalized in the cardiology department and anticoagulant therapy was initiated. The mechanical valve was, then, removed. On H15 postoperatively she was febrile with a temperature of (40°C), the pupils were isocoric, and there was a decerebrate rigidity, however, her hemodynamic state was stable. The PCR test result for COVID-19 was positive 15 hours after the surgery, a thoracic computer tomography angiography scan revealed a mild form of COVID-19. A brain computer tomography scan revealed a COVID-19 encephalopathy. Unfortunately at H20, the infectious workup showed leucocytosis and a positive CRP, which required initiating empiric antibiotic therapy with ceftriaxone and gentamicin awaiting for microscopy, culture and sensitivity results. Treatment with methylprednisolone was also started. The dose of immediate postoperative anticoagulation was maintained at 200 IU/Kg/D. On H24 her Glasgow Coma Scale was 3/15, pupils were fixed and dilated with loss of brainstem reflexes. Death was declared at Day 2 postoperatively as a result of neurological complications. Standard prophylactic and therapeutic protocols need to be reviewed when COVID-19 occurs in a patient with a mechanical valve prosthesis.
    VL  - 9
    IS  - 4
    ER  - 

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Author Information
  • Department of Thoracic and Cardio-Vascular Surgery, Fann Hospital, Dakar, Senegal

  • Department of Thoracic and Cardio-Vascular Surgery, Fann Hospital, Dakar, Senegal

  • Department of Thoracic and Cardio-Vascular Surgery, Fann Hospital, Dakar, Senegal

  • Cuomo Cardio-Pediatric Center in Fann Hospital, Dakar, Senegal

  • Department of Thoracic and Cardio-Vascular Surgery, Fann Hospital, Dakar, Senegal

  • Department of Thoracic and Cardio-Vascular Surgery, Fann Hospital, Dakar, Senegal

  • Department of Thoracic and Cardio-Vascular Surgery, Fann Hospital, Dakar, Senegal

  • Department of Thoracic and Cardio-Vascular Surgery, Fann Hospital, Dakar, Senegal

  • Department of Thoracic and Cardio-Vascular Surgery, Fann Hospital, Dakar, Senegal

  • Department of Thoracic and Cardio-Vascular Surgery, Fann Hospital, Dakar, Senegal

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